Ocular Surface RegenerationDry Eye Disease
Autologous serum eye drops for ocular surface disorders
Geerling G, Maclennan S, Hartwig D. · British Journal of Ophthalmology · 2004
Foundational review of the rationale, biochemistry, and clinical applications of autologous serum eye drops. Establishes growth factors (EGF, TGF-β, vitamin A, fibronectin) as the active mechanism for epithelial healing.
Autologous serum mirrors the biological composition of tears more closely than any pharmaceutical lubricant — making it uniquely suited for refractory ocular surface disease.
Full citation (AMA)
Geerling G, Maclennan S, Hartwig D. Autologous serum eye drops for ocular surface disorders. Br J Ophthalmol. 2004;88(11):1467-1474.
Dry Eye DiseaseASED as Adjunct
Autologous serum eye drops for dry eye (Cochrane Review)
Pan Q, Angelina A, Marrone M, et al. · Cochrane Database of Systematic Reviews · 2017
Systematic review of randomized trials comparing autologous serum eye drops to artificial tears or saline in patients with dry eye. Found short-term symptom improvement, particularly in severe disease.
ASED demonstrates meaningful short-term symptom relief in severe dry eye and is well-tolerated as an adjunct to standard therapy.
Full citation (AMA)
Pan Q, Angelina A, Marrone M, et al. Autologous serum eye drops for dry eye. Cochrane Database Syst Rev. 2017;2(2):CD009327.
GVHDDry Eye Disease
Autologous serum eye drops for the treatment of severe dry eye in patients with chronic GVHD
Ogawa Y, Okamoto S, Mori T, et al. · Bone Marrow Transplantation · 2003
Prospective study in chronic graft-versus-host disease patients with severe dry eye refractory to conventional therapy. Significant improvement in Schirmer scores, rose bengal staining, and symptom scores.
For GVHD-related severe dry eye, autologous serum delivers measurable surface restoration where artificial tears fail.
Full citation (AMA)
Ogawa Y, Okamoto S, Mori T, et al. Autologous serum eye drops for the treatment of severe dry eye in patients with chronic GVHD. Bone Marrow Transplant. 2003;31(7):579-583.
Neurotrophic KeratitisOcular Surface Regeneration
Autologous serum application in the treatment of neurotrophic keratopathy
Matsumoto Y, Dogru M, Goto E, et al. · Ophthalmology · 2004
Case series of neurotrophic keratopathy patients treated with autologous serum. Demonstrated epithelial healing, improved corneal sensation, and resolution of persistent epithelial defects.
Autologous serum supports neural and epithelial recovery in neurotrophic keratitis — particularly in eyes where bandage lenses and lubricants have plateaued.
Full citation (AMA)
Matsumoto Y, Dogru M, Goto E, et al. Autologous serum application in the treatment of neurotrophic keratopathy. Ophthalmology. 2004;111(6):1115-1120.
Post-refractiveDry Eye Disease
Autologous serum eye drops after LASIK
Noda-Tsuruya T, Asano-Kato N, Toda I, Tsubota K. · Journal of Refractive Surgery · 2006
Comparative study of autologous serum versus artificial tears for post-LASIK dry eye. Patients on serum showed faster corneal sensitivity recovery and superior symptom relief at 3 and 6 months.
Post-refractive dry eye recovers faster with autologous serum — an important option for patients with persistent symptoms after LASIK or PRK.
Full citation (AMA)
Noda-Tsuruya T, Asano-Kato N, Toda I, Tsubota K. Autologous serum eye drops for dry eye after LASIK. J Refract Surg. 2006;22(1):61-66.
Dry Eye DiseaseOcular Surface Regeneration
Treatment of dry eye by autologous serum application in Sjögren's syndrome
Tsubota K, Goto E, Fujita H, et al. · British Journal of Ophthalmology · 1999
Landmark study demonstrating autologous serum's efficacy in Sjögren's syndrome–related dry eye. Significant improvement in fluorescein and rose bengal staining and squamous metaplasia.
Sjögren's patients — historically among the hardest to treat — show measurable surface healing on autologous serum.
Full citation (AMA)
Tsubota K, Goto E, Fujita H, et al. Treatment of dry eye by autologous serum application in Sjögren's syndrome. Br J Ophthalmol. 1999;83(4):390-395.
